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Featured Holiday Homes in Mesilla

Pulsar · Brand New Comfortable 4/3.5 Home Near Parks

Pulsar · Brand New Comfortable 4/3.5 Home Near Parks

Las Cruces
With a stay at this vacation home in Las Cruces, you'll be within a 15-minute drive of New Mexico State University and Red Hawk Golf Club.
Pulsar · Brand New Comfortable 4/3.5 Home Near Parks
Casa Sonoma | Spacious, Central Retreat | Peloton

Casa Sonoma | Spacious, Central Retreat | Peloton

Las Cruces
With a stay at this vacation home in Las Cruces, you'll be next to a golf course, within a 10-minute drive of New Mexico State University and Sonoma Ranch Golf ...
Casa Sonoma | Spacious, Central Retreat | Peloton
Casita Azul, Mesilla Plaza Only Steps Away

Casita Azul, Mesilla Plaza Only Steps Away

Mesilla
With a stay at this vacation home in Mesilla, you'll be on a lake, within a 15-minute drive of New Mexico State University and Mesillia Plaza.
Casita Azul, Mesilla Plaza Only Steps Away
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Casa Alameda

Casa Alameda

Las Cruces
With a stay at this vacation home in Las Cruces, you'll be within a 5-minute drive of New Mexico State University and Las Cruces Museum of Art.
Casa Alameda
Pet-Friendly Las Cruces Home w/ Private Pool

Pet-Friendly Las Cruces Home w/ Private Pool

Las Cruces
With a stay at this vacation home in Las Cruces, you'll be within a 15-minute drive of Las Cruces Museum of Art and No Strings Theatre Company.
Pet-Friendly Las Cruces Home w/ Private Pool
Modern guesthouse on 11.5 amazing desert view acres.

Modern guesthouse on 11.5 amazing desert view acres.

Las Cruces
With a stay at this vacation home in Las Cruces, you'll be in the mountains, and 13.3 mi (21.4 km) from New Mexico State University and 7.7 mi (12.4 km) from ...
Modern guesthouse on 11.5 amazing desert view acres.
Charming Casita in historic Town of Mesilla,  NM  2392 Calle de Parian

Charming Casita in historic Town of Mesilla, NM 2392 Calle de Parian

Mesilla
The price is AU$365 per night from 6 Apr to 7 Apr
AU$365
includes taxes & fees
6 Apr - 7 Apr
With a stay at this vacation home in Mesilla, you'll be within a 15-minute drive of New Mexico State University and Mesillia Plaza.
Charming Casita in historic Town of Mesilla, NM 2392 Calle de Parian
Year Round Heated Pool, Hot Tub, Pet Friendly

Year Round Heated Pool, Hot Tub, Pet Friendly

Las Cruces
With a stay at this vacation home in Las Cruces, you'll be within a 10-minute drive of New Mexico State University and Mesilla Valley Mall.
Year Round Heated Pool, Hot Tub, Pet Friendly
Las Cruces Home w/ Mountain Views & Private Pool!

Las Cruces Home w/ Mountain Views & Private Pool!

Las Cruces
With a stay at this vacation home in Las Cruces, you'll be in the mountains, within a 10-minute drive of New Mexico State University and Sonoma Ranch Golf ...
Las Cruces Home w/ Mountain Views & Private Pool!
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Mesilla Holiday Houses

Do you love last minute road trips and late-night food runs and sunrises on the beach? Do words like “schedule” and “calendar” make you shout, “Don’t box me in!”? You might be a little bit of a rebel. But you’re a rebel with a cause: having a smashing holiday. Itinerary? What’s that? Our Mesilla vacation homes are the perfect way for you to wing it.

Holiday houses in Mesilla let you live life on your own terms. You’ll have so much space, you’ll wish you had more friends and family—but you can always invite over the neighbours. You can often have luxury amenities, but with all the attractions of Mesilla in your backyard, budget holiday homes will do just fine, too. That will just leave you more dough to spend on the important things: cocktails, brunch, and local Mesilla adventures, obvs.

If your adventure buddy happens to have fur and four legs, you just might find a pet-friendly holiday house in Mesilla with your name on it.

No need to spend big bickies for a holiday beach house the size of Buckingham Palace—unless you’re really in trouble with bae. We’ve got a great selection of Mesilla vacation homes with everything you need for a seriously amazing getaway. Throw out that daily planner and hit “reject” on all those meeting invites. You’re off to a place where there are no rules.

Mesilla Holiday Homes essential information

Accommodation
194 Holiday Homes
Lowest Price
AU$121
Highest Price
AU$365
Popular accommodation
Pulsar · Brand New Comfortable 4/3.5 Home Near Parks, Casa Sonoma | Spacious, Central Retreat | Peloton, Casita Azul, Mesilla Plaza Only Steps Away, Casa Alameda, Pet-Friendly Las Cruces Home w/ Private Pool, Modern guesthouse on 11.5 amazing desert view acres. , Charming Casita in historic Town of Mesilla, NM 2392 Calle de Parian, Year Round Heated Pool, Hot Tub, Pet Friendly, Las Cruces Home w/ Mountain Views & Private Pool!

Top trending hotels in Mesilla

Casita Azul, Mesilla Plaza Only Steps Away

Casita Azul, Mesilla Plaza Only Steps Away

Mesilla
With a stay at this vacation home in Mesilla, you'll be on a lake, within a 15-minute drive of New Mexico State University and Mesillia Plaza.
Casita Azul, Mesilla Plaza Only Steps Away
Charming Casita in historic Town of Mesilla,  NM  2392 Calle de Parian

Charming Casita in historic Town of Mesilla, NM 2392 Calle de Parian

Mesilla
The price is AU$365 per night from 6 Apr to 7 Apr
AU$365
includes taxes & fees
6 Apr - 7 Apr
With a stay at this vacation home in Mesilla, you'll be within a 15-minute drive of New Mexico State University and Mesillia Plaza.
Charming Casita in historic Town of Mesilla, NM 2392 Calle de Parian
Hotel Encanto de Las Cruces

Hotel Encanto de Las Cruces

3.5 out of 5
705 S Telshor Blvd, Las Cruces, NM
Fully refundableReserve now, pay when you stay
The price is AU$266 per night from 19 Apr to 20 Apr
AU$266
includes taxes & fees
19 Apr - 20 Apr
With a stay at Hotel Encanto de Las Cruces in Las Cruces, you'll be within a 5-minute drive of New Mexico State University and Mesilla Valley Mall.
Hotel Encanto de Las Cruces
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La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain

La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain

2.5 out of 5
1500 Hickory Dr, Las Cruces, NM
Fully refundableReserve now, pay when you stay
The price is AU$121 per night from 20 Apr to 21 Apr
AU$121
includes taxes & fees
20 Apr - 21 Apr
With a stay at La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain in Las Cruces, you'll be in the historical district, within a 15-minute drive of New ...
La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain
Don't see what you're looking for?
See all available properties in Mesilla
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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^Subject to availability and chosen travel dates.