Book Holiday Homes in Pickens

More Flash, Less Cash - Take advantage of our Price Pledge** (even on luxey stays)

We keep it easy with the option to pay now or later on select accommodation

Book up 'til the last second - millions of rooms to crash tonight^

Featured Holiday Homes in Pickens

Serene 4-bedroom house in Greenville with WiFi

Serene 4-bedroom house in Greenville with WiFi

Greenville
The price is AU$408 per night from 28 Dec to 29 Dec
AU$408
includes taxes & fees
28 Dec - 29 Dec
Located in Greenville, this vacation home is within a 5-minute drive of Greenville Cultural Exchange Center and Bi Lo Center.
Serene 4-bedroom house in Greenville with WiFi
6 Bedrooms and 3 docks on a Lake Hartwell cove, 3 miles from Clemson by water.

6 Bedrooms and 3 docks on a Lake Hartwell cove, 3 miles from Clemson by water.

Seneca
With a stay at this vacation home in Seneca, you'll be on the waterfront, within a 15-minute drive of Clemson University and Lake Hartwell.
6 Bedrooms and 3 docks on a Lake Hartwell cove, 3 miles from Clemson by water.
Main Street Alchemy Walkable Downtown Brevard Home

Main Street Alchemy Walkable Downtown Brevard Home

2 out of 5
Brevard
A stay at this vacation home places you in the heart of Brevard, within a 10-minute walk of Transylvania Heritage Museum and Crystal Mountain Gem Mine.
Main Street Alchemy Walkable Downtown Brevard Home
Save an average of 15% on thousands of hotels when you're signed in
Private, pet-friendly adorable getaway mins to downtown

Private, pet-friendly adorable getaway mins to downtown

Greenville
The price is AU$501 per night from 3 Jan to 4 Jan
AU$501
includes taxes & fees
3 Jan - 4 Jan 2025
A stay at this vacation home places you in the heart of Greenville, within a 5-minute drive of Swamp Rabbit Trail and Greenville Cultural Exchange Center.
Private, pet-friendly adorable getaway mins to downtown
New Luxury Townhouse - Central to Downtown Greenville

New Luxury Townhouse - Central to Downtown Greenville

Greenville
The price is AU$653 per night from 16 Jan to 17 Jan
AU$653
includes taxes & fees
16 Jan - 17 Jan 2025
A stay at this vacation home places you in the heart of Greenville, within a 10-minute walk of Upcountry History Museum and Heritage Green.
New Luxury Townhouse - Central to Downtown Greenville
Charming 5 Bedroom Spacious Home 12 mins to Downtown Greenville

Charming 5 Bedroom Spacious Home 12 mins to Downtown Greenville

Piedmont
Located in Piedmont, this vacation home is a 4-minute drive from Greenville Hospital and 7 minutes from Blythwood Commons.
Charming 5 Bedroom Spacious Home 12 mins to Downtown Greenville
GORGEOUS 2 BR on MAIN #4

GORGEOUS 2 BR on MAIN #4

Greenville
The price is AU$556 per night from 5 Jan to 6 Jan
AU$556
includes taxes & fees
5 Jan - 6 Jan 2025
With a stay at this vacation home in Greenville (Greenville Downtown), you'll be steps from Falls Park on the Reedy and 3 minutes by foot from Warehouse ...
GORGEOUS 2 BR on MAIN #4
Boutique hotel in historic downtown Seneca. Room #6, King Bed.

Boutique hotel in historic downtown Seneca. Room #6, King Bed.

Seneca
The price is AU$339 per night from 23 Dec to 24 Dec
AU$339
includes taxes & fees
23 Dec - 24 Dec
With a stay at this vacation home in Seneca, you'll be within a 10-minute drive of Clemson University and The Gauntlet.
Boutique hotel in historic downtown Seneca. Room #6, King Bed.
Peaceful Six Mile Vacation Home w/ Fire Pit

Peaceful Six Mile Vacation Home w/ Fire Pit

Six Mile
With a stay at this vacation home in Six Mile, you'll be within a 15-minute drive of Lake Keowee and Lake Hartwell.
Peaceful Six Mile Vacation Home w/ Fire Pit
Don't see what you're looking for?
See all available properties in Pickens
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Pickens Holiday Houses

Do you love last minute road trips and late-night food runs and sunrises on the beach? Do words like “schedule” and “calendar” make you shout, “Don’t box me in!”? You might be a little bit of a rebel. But you’re a rebel with a cause: having a smashing holiday. Itinerary? What’s that? Our Pickens vacation homes are the perfect way for you to wing it.

Holiday houses in Pickens let you live life on your own terms. You’ll have so much space, you’ll wish you had more friends and family—but you can always invite over the neighbours. You can often have luxury amenities, but with all the attractions of Pickens in your backyard, budget holiday homes will do just fine, too. That will just leave you more dough to spend on the important things: cocktails, brunch, and local Pickens adventures, obvs.

If your adventure buddy happens to have fur and four legs, you just might find a pet-friendly holiday house in Pickens with your name on it.

No need to spend big bickies for a holiday beach house the size of Buckingham Palace—unless you’re really in trouble with bae. We’ve got a great selection of Pickens vacation homes with everything you need for a seriously amazing getaway. Throw out that daily planner and hit “reject” on all those meeting invites. You’re off to a place where there are no rules.

Pickens Holiday Homes essential information

Accommodation
1124 Holiday Homes
Lowest Price
AU$124
Highest Price
AU$653
Popular accommodation
Serene 4-bedroom house in Greenville with WiFi, 6 Bedrooms and 3 docks on a Lake Hartwell cove, 3 miles from Clemson by water., Main Street Alchemy Walkable Downtown Brevard Home, Private, pet-friendly adorable getaway mins to downtown, New Luxury Townhouse - Central to Downtown Greenville, Charming 5 Bedroom Spacious Home 12 mins to Downtown Greenville, GORGEOUS 2 BR on MAIN #4, Boutique hotel in historic downtown Seneca. Room #6, King Bed., Peaceful Six Mile Vacation Home w/ Fire Pit

Top trending hotels in Pickens

Hilton Greenville

Hilton Greenville

3.5 out of 5
45 W Orchard Park Dr, Greenville, SC
Fully refundableReserve now, pay when you stay
The price is AU$180 per night from 4 Jan to 5 Jan
AU$180
includes taxes & fees
4 Jan - 5 Jan 2025
When you stay at Hilton Greenville in Greenville, you'll be in the business district, within a 5-minute drive of Patewood Memorial Hospital and Haywood ...
Hilton Greenville
Hyatt Regency Greenville

Hyatt Regency Greenville

3.5 out of 5
220 N Main St, Greenville, SC
Fully refundableReserve now, pay when you stay
The price is AU$228 per night from 30 Dec to 31 Dec
AU$228
includes taxes & fees
30 Dec - 31 Dec
With a stay at Hyatt Regency Greenville, you'll be centrally located in Greenville, within a 10-minute walk of The Peace Center and Falls Park on the Reedy.
Hyatt Regency Greenville
La Quinta Inn & Suites by Wyndham Greenville Haywood

La Quinta Inn & Suites by Wyndham Greenville Haywood

2.5 out of 5
65 W Orchard Park Dr, Greenville, SC
Fully refundableReserve now, pay when you stay
The price is AU$124 per night from 29 Dec to 30 Dec
AU$124
includes taxes & fees
29 Dec - 30 Dec
Located in Greenville, La Quinta Inn & Suites by Wyndham Greenville Haywood is within a 15-minute walk of CrossWinds Golf Club and Haywood Mall.
La Quinta Inn & Suites by Wyndham Greenville Haywood
Save an average of 15% on thousands of hotels when you're signed in
Best Western Plus Greenville I-385 Inn & Suites

Best Western Plus Greenville I-385 Inn & Suites

2.5 out of 5
831 Congaree Rd, Greenville, SC
Fully refundableReserve now, pay when you stay
The price is AU$149 per night from 29 Dec to 30 Dec
AU$149
includes taxes & fees
29 Dec - 30 Dec
A stay at Best Western Plus Greenville I-385 Inn & Suites places you in the heart of Greenville, within a 5-minute drive of The Shops at Greenridge and St. Francis ...
Best Western Plus Greenville I-385 Inn & Suites
Don't see what you're looking for?
See all available properties in Pickens
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

**Terms and Conditions apply.
^Subject to availability and chosen travel dates.