Book Holiday Homes in Santa Cruz

More Flash, Less Cash - Take advantage of our Price Pledge** (even on luxey stays)

We keep it easy with the option to pay now or later on select accommodation

Book up 'til the last second - millions of rooms to crash tonight^

Featured Holiday Homes in Santa Cruz

Mi casa su casa, moderna y chic.

Mi casa su casa, moderna y chic.

Santa Cruz de la Sierra
The price is AU$101 per night from 28 Jan to 29 Jan
AU$101
includes taxes & fees
28 Jan - 29 Jan 2025
When you stay at this vacation home in Santa Cruz, you'll be within a 10-minute drive of Univalle and Play Land Amusement Park.
Mi casa su casa, moderna y chic.
Casa Vida

Casa Vida

3.5 out of 5
Condominio Club Campestre, Kilometro 13 doble via La Guardia, Santa Cruz, Santa
Located in Santa Cruz, Casa Vida is in a rural location, within a 15-minute drive of Parque Ecológico and Ramon Tahuichi Aguilera Stadium.
Casa Vida
Cozy and independent.<br>Downtown house JH.

Cozy and independent.<br>Downtown house JH.

Santa Cruz de la Sierra
The price is AU$86 per night from 30 Dec to 31 Dec
AU$86
includes taxes & fees
30 Dec - 31 Dec
Located in Santa Cruz, this vacation home is within a 5-minute drive of Cine Center and Blacutt Square.
Cozy and independent.<br>Downtown house JH.
Save an average of 15% on thousands of hotels when you're signed in
Jose Luis Noya

Jose Luis Noya

Santa Cruz de la Sierra
With a stay at this vacation home in Santa Cruz, you'll be within a 15-minute drive of Parque Ecológico and Ramon Tahuichi Aguilera Stadium.
Jose Luis Noya
Quiet, cozy, . Ideal to rest without noise

Quiet, cozy, . Ideal to rest without noise

Santa Cruz de la Sierra
The price is AU$76 per night from 30 Dec to 31 Dec
AU$76
includes taxes & fees
30 Dec - 31 Dec
When you stay at this vacation home in Santa Cruz, you'll be within a 10-minute drive of Parque Ecológico and Ramon Tahuichi Aguilera Stadium.
Quiet, cozy, . Ideal to rest without noise
Aguas Calientes a heavenly place

Aguas Calientes a heavenly place

Roboré
The price is AU$201 per night from 30 Dec to 31 Dec
AU$201
includes taxes & fees
30 Dec - 31 Dec
With a stay at this vacation home in Santa Cruz, you'll be within a 5-minute drive of Cine Center and Catedral de Santa Cruz.
Aguas Calientes a heavenly place
⭐️Casa entera de 4 dormitorios pasos de EXPOCRUZ , parkeo incluido 2/3 autos

⭐️Casa entera de 4 dormitorios pasos de EXPOCRUZ , parkeo incluido 2/3 autos

Santa Cruz de la Sierra
Located in Santa Cruz, this vacation home is within a 15-minute walk of Patio Design LifeStyle Center and Parque Ecológico.
⭐️Casa entera de 4 dormitorios pasos de EXPOCRUZ , parkeo incluido 2/3 autos
Posada Express by Transit Inn Aeropuerto Viru Viru

Posada Express by Transit Inn Aeropuerto Viru Viru

Santa Cruz de la Sierra
The price is AU$116 per night from 30 Dec to 31 Dec
AU$116
includes taxes & fees
30 Dec - 31 Dec
Located in Santa Cruz, this vacation home is within a 5-minute drive of Patio Design LifeStyle Center and Municipal Library.
Posada Express by Transit Inn Aeropuerto Viru Viru
Casa independiente estilo rustico. Ideal para familias o grupo de amigos.

Casa independiente estilo rustico. Ideal para familias o grupo de amigos.

Santa Cruz de la Sierra
The price is AU$188 per night from 30 Dec to 31 Dec
AU$188
includes taxes & fees
30 Dec - 31 Dec
Located in Santa Cruz, this vacation home is a 2-minute drive from Catedral de Santa Cruz and 7 minutes from Cine Center.
Casa independiente estilo rustico. Ideal para familias o grupo de amigos.
Don't see what you're looking for?
See all available properties in Santa Cruz
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Santa Cruz Holiday Houses

Do you love last minute road trips and late-night food runs and sunrises on the beach? Do words like “schedule” and “calendar” make you shout, “Don’t box me in!”? You might be a little bit of a rebel. But you’re a rebel with a cause: having a smashing holiday. Itinerary? What’s that? Our Santa Cruz vacation homes are the perfect way for you to wing it.

Holiday houses in Santa Cruz let you live life on your own terms. You’ll have so much space, you’ll wish you had more friends and family—but you can always invite over the neighbours. You can often have luxury amenities, but with all the attractions of Santa Cruz in your backyard, budget holiday homes will do just fine, too. That will just leave you more dough to spend on the important things: cocktails, brunch, and local Santa Cruz adventures, obvs.

If your adventure buddy happens to have fur and four legs, you just might find a pet-friendly holiday house in Santa Cruz with your name on it.

No need to spend big bickies for a holiday beach house the size of Buckingham Palace—unless you’re really in trouble with bae. We’ve got a great selection of Santa Cruz vacation homes with everything you need for a seriously amazing getaway. Throw out that daily planner and hit “reject” on all those meeting invites. You’re off to a place where there are no rules.

Santa Cruz Holiday Homes essential information

Accommodation
13 Holiday Homes
Lowest Price
AU$76
Highest Price
AU$201
Popular accommodation
Mi casa su casa, moderna y chic., Casa Vida, Cozy and independent.
Downtown house JH., Jose Luis Noya, Quiet, cozy, . Ideal to rest without noise, Aguas Calientes a heavenly place, ⭐️Casa entera de 4 dormitorios pasos de EXPOCRUZ , parkeo incluido 2/3 autos, Posada Express by Transit Inn Aeropuerto Viru Viru, Casa independiente estilo rustico. Ideal para familias o grupo de amigos.

Top trending hotels in Santa Cruz

Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel

5 out of 5
4to Anillo Entre Radial 23, At Calle Las Ramblas, Santa Cruz, Santa Cruz
The price is AU$168 per night from 10 Jan to 11 Jan
AU$168
includes taxes & fees
10 Jan - 11 Jan 2025
Located in Santa Cruz, Marriott Santa Cruz de la Sierra Hotel is in the business district, within a 5-minute drive of Ventura Mall and Santa Cruz Zoo.
Marriott Santa Cruz de la Sierra Hotel
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455, Santa Cruz
The price is AU$196 per night from 27 Jan to 28 Jan
AU$196
includes taxes & fees
27 Jan - 28 Jan 2025
When you stay at Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel in Santa Cruz, you'll be connected to the convention center, within a 15-minute ...
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

4.5 out of 5
San Martin Avenue Esq Street E - E, Santa Cruz
The price is AU$121 per night from 1 Jan to 2 Jan
AU$121
includes taxes & fees
1 Jan - 2 Jan 2025
Located in Santa Cruz, Hampton by Hilton Santa Cruz/Equipetrol, Bolivia is in the business district, within a 5-minute drive of Ventura Mall and Santa Cruz ...
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
Save an average of 15% on thousands of hotels when you're signed in
Camino Real Hotel

Camino Real Hotel

4.5 out of 5
Av. San Martín y 4to. Anillo, Equipetrol Norte, Santa Cruz
The price is AU$178 per night from 3 Jan to 4 Jan
AU$178
includes taxes & fees
3 Jan - 4 Jan 2025
Located in Santa Cruz, Camino Real Hotel is in the business district, just a 3-minute walk from Ventura Mall and a 3-minute drive from Santa Cruz Zoo.
Camino Real Hotel
Don't see what you're looking for?
See all available properties in Santa Cruz
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More ways to explore Santa Cruz

**Terms and Conditions apply.
^Subject to availability and chosen travel dates.