Book Holiday Homes in Santa Isabel

More Flash, Less Cash - Take advantage of our Price Pledge** (even on luxey stays)

We keep it easy with the option to pay now or later on select accommodation

Book up 'til the last second - millions of rooms to crash tonight^

Featured Holiday Homes in Santa Isabel

Hacienda Margarita Mountain Top Inn & Panoramic Pool in Central Puerto Rico

Hacienda Margarita Mountain Top Inn & Panoramic Pool in Central Puerto Rico

Barranquitas
The price is AU$216 per night from 23 Jan to 24 Jan
AU$216
includes taxes & fees
23 Jan - 24 Jan
When you stay at this vacation home in Barranquitas, you'll be 7 minutes by car from Finca Don Felix para la Naturaleza.
Hacienda Margarita Mountain Top Inn & Panoramic Pool in Central Puerto Rico
Beach House w/ pool/ac/wifi/cable/ Salinas PR

Beach House w/ pool/ac/wifi/cable/ Salinas PR

4 out of 5
Salinas
Located in Salinas, this vacation home is a 2-minute drive from Marina de Salinas and 5 minutes from Playa La Ochenta.
Beach House w/ pool/ac/wifi/cable/ Salinas PR
Charming house, stunning views in brilliant Barranquitas with AC, WiFi, Parking

Charming house, stunning views in brilliant Barranquitas with AC, WiFi, Parking

2 out of 5
Barranquitas
When you stay at this vacation home in Barranquitas, you'll be in the mountains and within a 5-minute drive of Finca Don Felix para la Naturaleza.
Charming house, stunning views in brilliant Barranquitas with AC, WiFi, Parking
Save an average of 15% on thousands of hotels when you're signed in
Complete Remodel House quite 2 minutes from beach Urbanizacion Vista del Sol.

Complete Remodel House quite 2 minutes from beach Urbanizacion Vista del Sol.

Guayama
When you stay at this vacation home in Guayama, you'll be 12 minutes by foot from Museo Casa Cautino.
Complete Remodel House quite 2 minutes from beach Urbanizacion Vista del Sol.
Oasis Salinas

Oasis Salinas

Salinas
A stay at this vacation home places you in the heart of Salinas, within a 5-minute drive of Marina de Salinas and Playa La Ochenta.
Oasis Salinas
Discover Guayama's Tropical Treasure: Your Home Away From Home.

Discover Guayama's Tropical Treasure: Your Home Away From Home.

Guayama
Located in Guayama, this vacation home is by the sea, within a 15-minute drive of Museo Casa Cautino and Albergue Olimpico.
Discover Guayama's Tropical Treasure: Your Home Away From Home.
Casa Boni Guest House, Vista única al lago de Carite

Casa Boni Guest House, Vista única al lago de Carite

Guayama
With a stay at this vacation home in Guayama, you'll be on a lake, and 13.7 mi (22 km) from Balneario Punta Guilarte and 15.2 mi (24.5 km) from Playa ...
Casa Boni Guest House, Vista única al lago de Carite
Peaceful place

Peaceful place

Ponce
Located in Ponce, this vacation home is by the sea, within a 10-minute drive of Vicens Coliseum and Montaner Stadium.
Peaceful place
Caribbean Beach Front Gem 1&2, Family Vacation Compound

Caribbean Beach Front Gem 1&2, Family Vacation Compound

Guayama
Located in Guayama, this vacation home is by the ocean, a 1-minute drive from Playa Pozuelo and 9 minutes from Reserva Nacional de Investigación Estuarina de ...
Caribbean Beach Front Gem 1&2, Family Vacation Compound
Don't see what you're looking for?
See all available properties in Santa Isabel
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Santa Isabel Holiday Houses

Do you love last minute road trips and late-night food runs and sunrises on the beach? Do words like “schedule” and “calendar” make you shout, “Don’t box me in!”? You might be a little bit of a rebel. But you’re a rebel with a cause: having a smashing holiday. Itinerary? What’s that? Our Santa Isabel vacation homes are the perfect way for you to wing it.

Holiday houses in Santa Isabel let you live life on your own terms. You’ll have so much space, you’ll wish you had more friends and family—but you can always invite over the neighbours. You can often have luxury amenities, but with all the attractions of Santa Isabel in your backyard, budget holiday homes will do just fine, too. That will just leave you more dough to spend on the important things: cocktails, brunch, and local Santa Isabel adventures, obvs.

If your adventure buddy happens to have fur and four legs, you just might find a pet-friendly holiday house in Santa Isabel with your name on it.

No need to spend big bickies for a holiday beach house the size of Buckingham Palace—unless you’re really in trouble with bae. We’ve got a great selection of Santa Isabel vacation homes with everything you need for a seriously amazing getaway. Throw out that daily planner and hit “reject” on all those meeting invites. You’re off to a place where there are no rules.

Santa Isabel Holiday Homes essential information

Accommodation
63 Holiday Homes
Lowest Price
AU$143
Highest Price
AU$589
Popular accommodation
Hacienda Margarita Mountain Top Inn & Panoramic Pool in Central Puerto Rico, Beach House w/ pool/ac/wifi/cable/ Salinas PR, Charming house, stunning views in brilliant Barranquitas with AC, WiFi, Parking, Complete Remodel House quite 2 minutes from beach Urbanizacion Vista del Sol., Oasis Salinas , Discover Guayama's Tropical Treasure: Your Home Away From Home. , Casa Boni Guest House, Vista única al lago de Carite, Peaceful place, Caribbean Beach Front Gem 1&2, Family Vacation Compound

Top trending hotels in Santa Isabel

Hotel Las Vegas

Hotel Las Vegas

3 out of 5
PR 153, Km 2.9, Santa Isabel
The price is AU$143 per night from 17 Jan to 18 Jan
AU$143
includes taxes & fees
17 Jan - 18 Jan
With a stay at Hotel Las Vegas in Santa Isabel, you'll be within a 15-minute drive of Coamo Springs and Playa La Ochenta.
Hotel Las Vegas
Cultural Oasis: Beachfront Gem, Puerto Rican Heritage at Your Doorstep

Cultural Oasis: Beachfront Gem, Puerto Rican Heritage at Your Doorstep

Santa Isabel
The price is AU$589 per night from 19 Jan to 20 Jan
AU$589
includes taxes & fees
19 Jan - 20 Jan
Located in Santa Isabel, this vacation home is by the ocean, within a 15-minute drive of Playa La Ochenta and Marina de Salinas.
Cultural Oasis: Beachfront Gem, Puerto Rican Heritage at Your Doorstep
Villa Serena en Santa Isabel P.R

Villa Serena en Santa Isabel P.R

Santa Isabel
When you stay at this vacation home in Santa Isabel, you'll be 10 minutes by car from Coamo Springs.
Villa Serena en Santa Isabel P.R
Save an average of 15% on thousands of hotels when you're signed in
Modern Cozy Home in Puerto Rican Paradise

Modern Cozy Home in Puerto Rican Paradise

Santa Isabel
With a stay at this vacation home in Santa Isabel, you'll be within a 15-minute drive of Playa La Ochenta and Coamo Springs.
Modern Cozy Home in Puerto Rican Paradise
Don't see what you're looking for?
See all available properties in Santa Isabel
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

**Terms and Conditions apply.
^Subject to availability and chosen travel dates.