Book Seneca hotels

More Flash, Less Cash - Take advantage of our Price Pledge** (even on luxey stays)

We keep it easy with the option to pay now or later on select accommodation

Book up 'til the last second - millions of rooms to crash tonight^

Check hotel availability in Seneca

Cheap Seneca hotels

Lakeside Lodge Clemson

Lakeside Lodge Clemson

2.5 out of 5
13500 Clemson Blvd, Seneca, SC
Fully refundableReserve now, pay when you stay
The price is AU$215 per night from 23 Dec to 24 Dec
AU$215
includes taxes & fees
23 Dec - 24 Dec
With a stay at Lakeside Lodge Clemson in Seneca, you'll be within a 5-minute drive of Clemson University and Lake Hartwell.
Lakeside Lodge Clemson
Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson

2.5 out of 5
13050 Clemson Blvd, Seneca, SC
Fully refundableReserve now, pay when you stay
The price is AU$193 per night from 28 Dec to 29 Dec
AU$193
includes taxes & fees
28 Dec - 29 Dec
When you stay at Tru by Hilton Seneca Clemson in Seneca, you'll be in a shopping district, within a 5-minute drive of Clemson University and Littlejohn ...
Tru by Hilton Seneca Clemson
Quality Inn Seneca US-123

Quality Inn Seneca US-123

2.5 out of 5
226 Hi Tech Rd, Seneca, SC
Fully refundableReserve now, pay when you stay
The price is AU$176 per night from 13 Jan to 14 Jan
AU$176
includes taxes & fees
13 Jan - 14 Jan 2025
With a stay at Quality Inn Seneca US-123, you'll be centrally located in Seneca, within a 15-minute drive of Clemson University and The Gauntlet.
Quality Inn Seneca US-123
Save an average of 15% on thousands of hotels when you're signed in
Best Western Seneca-Clemson

Best Western Seneca-Clemson

2.5 out of 5
511 Bypass Highway 123, Seneca, SC
Fully refundableReserve now, pay when you stay
The price is AU$163 per night from 28 Dec to 29 Dec
AU$163
includes taxes & fees
28 Dec - 29 Dec
With a stay at Best Western Seneca-Clemson in Seneca, you'll be within a 10-minute drive of Clemson University and Lake Keowee.
Best Western Seneca-Clemson
Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

2.5 out of 5
1011 East North 1st Street, Seneca, SC
Fully refundableReserve now, pay when you stay
The price is AU$213 per night from 24 Dec to 25 Dec
AU$213
includes taxes & fees
24 Dec - 25 Dec
With a stay at Hampton Inn & Suites Seneca-Clemson Area in Seneca, you'll be in the business district, within a 10-minute drive of Clemson University and Wyndham ...
Hampton Inn & Suites Seneca-Clemson Area
Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area

2 out of 5
11015 N Radio Station Rd, Seneca, SC
Fully refundableReserve now, pay when you stay
The price is AU$127 per night from 24 Dec to 25 Dec
AU$127
includes taxes & fees
24 Dec - 25 Dec
With a stay at Days Inn by Wyndham Seneca / Clemson Area in Seneca, you'll be in the business district, within a 15-minute drive of Clemson University and Applewood ...
Days Inn by Wyndham Seneca / Clemson Area
Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area

2.5 out of 5
800 BYPASS 123, Seneca, SC
Fully refundableReserve now, pay when you stay
The price is AU$227 per night from 23 Dec to 24 Dec
AU$227
includes taxes & fees
23 Dec - 24 Dec
With a stay at Fairfield Inn & Suites Seneca Clemson Univ Area in Seneca, you'll be on a lake, within a 10-minute drive of Clemson University and Lake ...
Fairfield Inn & Suites Seneca Clemson Univ Area
5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!

5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!

Seneca
Located in Seneca, this vacation home is on the waterfront, within a 15-minute drive of Lake Keowee and Golden Corner Plaza.
5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!
4/3 Waterfront Home w/ Covered Dock,  2 Decks, Pet Friendly. Long view on lake.

4/3 Waterfront Home w/ Covered Dock, 2 Decks, Pet Friendly. Long view on lake.

Seneca
Located in Seneca, this vacation home is on the waterfront, within a 15-minute drive of Lake Keowee and Keowee Key Golf Course.
4/3 Waterfront Home w/ Covered Dock, 2 Decks, Pet Friendly. Long view on lake.
Don't see what you're looking for?
See all available properties in Seneca
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Seneca, Anderson

Sick of hearing about ROIs and KPIs when you'd rather be relaxing somewhere with a G&T? Get away from the office (and all that boring jargon) and book a hotel in Seneca. You’ll find it 35 kilometres from the heart of Anderson.

The more money you save on accommodation, the more you'll have to treat yo-self with! The Days Inn Seneca Clemson SC is among the only budget hotels here, so there's no time to dilly dally.

'Don't talk to me till I've had my morning coffee'. If this sounds like the type of thing you'd say, you'll be relieved to know that BREWS on the Alley is within cooee. When you feel up to some nosh later, toddle on over and peruse the menu at Ram Cat Social House.

Accommodation options near Seneca

We know it's a bit tiresome, but hotels in Seneca are sometimes fully booked. Don't stress though! Why not get in early and have a gander at the offerings in our Clemson hotels guide? Clemson is 12 kilometres from Seneca.

There's nothing like stepping off a plane and into a new and exotic place. Hotels, flights, experiences, rental cars — whatever you need, lastminute.com.au will make it happen!

Seneca hotels essential information

Accommodation
1,499 hotels
Lowest Price
AU$127
Highest Price
AU$227
Popular hotels
Lakeside Lodge Clemson, Tru by Hilton Seneca Clemson, Quality Inn Seneca US-123, Best Western Seneca-Clemson, Hampton Inn & Suites Seneca-Clemson Area, Days Inn by Wyndham Seneca / Clemson Area, Fairfield Inn & Suites Seneca Clemson Univ Area , 5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!, 4/3 Waterfront Home w/ Covered Dock, 2 Decks, Pet Friendly. Long view on lake.

Most recent Seneca hotel reviews

**Terms and Conditions apply.
^Subject to availability and chosen travel dates.