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Top trending hotels in South Central Houston

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

3.5 out of 5
6633 Travis St, Houston, TX
Fully refundableReserve now, pay when you stay
The price is AU$185 per night from 20 Apr to 21 Apr
AU$185
includes taxes & fees
20 Apr - 21 Apr
With a stay at Hilton Houston Plaza/Medical Center, you'll be centrally located in Houston, within a 5-minute drive of MD Anderson Cancer Center and Rice ...
Hilton Houston Plaza/Medical Center
InterContinental Houston by IHG

InterContinental Houston by IHG

4 out of 5
6750 Main St, Houston, TX
Fully refundable
The price is AU$302 per night from 20 Apr to 21 Apr
AU$302
includes taxes & fees
20 Apr - 21 Apr
With a stay at InterContinental Houston by IHG, you'll be centrally located in Houston, within a 10-minute walk of Houston Methodist Hospital and Texas Children's ...
InterContinental Houston by IHG
Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 out of 5
5701 Main Street, Houston, TX
Fully refundableReserve now, pay when you stay
The price is AU$553 per night from 21 Apr to 22 Apr
AU$553
includes taxes & fees
21 Apr - 22 Apr
With a stay at Hotel Zaza Houston Museum District, you'll be centrally located in Houston, within a 5-minute drive of Rice University and MD Anderson Cancer ...
Hotel Zaza Houston Museum District
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DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites

4 out of 5
6800 Main Street, Houston, TX
Fully refundableReserve now, pay when you stay
The price is AU$218 per night from 27 Apr to 28 Apr
AU$218
includes taxes & fees
27 Apr - 28 Apr
Centrally located in Houston, DoubleTree by Hilton Houston Medical Center Hotel & Suites is within a 15-minute walk of MD Anderson Cancer Center and Hermann ...
DoubleTree by Hilton Houston Medical Center Hotel & Suites
The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District

4 out of 5
1709 DRYDEN ROAD, Houston, TX
Fully refundableReserve now, pay when you stay
The price is AU$410 per night from 30 Apr to 1 May
AU$410
includes taxes & fees
30 Apr - 1 May
With a stay at The Westin Houston Medical Center/Museum District in Houston (Texas Medical Center), you'll be within a 5-minute drive of Houston Zoo and Hermann ...
The Westin Houston Medical Center/Museum District
Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District

4 out of 5
6580 Fannin Street, Houston, TX
Fully refundableReserve now, pay when you stay
With a stay at Houston Marriott Medical Center/Museum District in Houston (Texas Medical Center), you'll be steps from Houston Methodist Hospital and 3 minutes ...
Houston Marriott Medical Center/Museum District
Extended Stay America Suites Houston Med Ctr Braeswood Bl

Extended Stay America Suites Houston Med Ctr Braeswood Bl

2.5 out of 5
1301 Braeswood Blvd, Houston, TX
Fully refundableReserve now, pay when you stay
The price is AU$128 per night from 30 Apr to 1 May
AU$128
includes taxes & fees
30 Apr - 1 May
With a stay at Extended Stay America Suites Houston Med Ctr Braeswood Bl in Houston (Texas Medical Center), you'll be within a 5-minute drive of MD Anderson ...
Extended Stay America Suites Houston Med Ctr Braeswood Bl
Americas Best Value Inn Medical Center Downtown

Americas Best Value Inn Medical Center Downtown

2 out of 5
2419 Riverside Dr, Houston, TX
Fully refundableReserve now, pay when you stay
The price is AU$155 per night from 30 Apr to 1 May
AU$155
includes taxes & fees
30 Apr - 1 May
A stay at Americas Best Value Inn Medical Center Downtown places you in the heart of Houston, within a 5-minute drive of Children's Museum of Houston and Houston ...
Americas Best Value Inn Medical Center Downtown
Hilton University of Houston

Hilton University of Houston

3.5 out of 5
4450 University Drive, Houston, TX
Fully refundableReserve now, pay when you stay
The price is AU$282 per night from 27 Apr to 28 Apr
AU$282
includes taxes & fees
27 Apr - 28 Apr
With a stay at Hilton University of Houston in Houston (Southeast Houston), you'll be a 2-minute drive from University of Houston and 6 minutes from Toyota ...
Hilton University of Houston
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

South Central Houston Hotels

Haven’t you been dying to check out that swanky new coffee shop? What about the recently opened bar serving drinks in mason jars? And let’s not forget about the barber shops willing to give you a shaved-on-the-sides, long-on-top cut whenever you want. Don’t worry; we’ll help you find the best deals at hotels in South Central Houston.

This hip new ’hood will charm the-you-know-what off you. South Central Houston hotels are comfortable and affordable, and many offer amenities like room service for those late-night meals, as well as a pool to swim in. Some of these hotels will also have you near great shopping such as souvenir shops, clothing boutiques and everything in between. Don’t feel like leaving the hotel for dinner and drinks? Hang out in the lobby bar and meet some of your fellow travellers—you never what kinds of stories they have in their memory log.

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South Central Houston hotels essential information

Accommodation
1,137 hotels
Lowest Price
AU$128
Highest Price
AU$553
Popular hotels
Hilton Houston Plaza/Medical Center, InterContinental Houston by IHG, Hotel Zaza Houston Museum District, DoubleTree by Hilton Houston Medical Center Hotel & Suites, The Westin Houston Medical Center/Museum District, Houston Marriott Medical Center/Museum District, Extended Stay America Suites Houston Med Ctr Braeswood Bl, Americas Best Value Inn Medical Center Downtown, Hilton University of Houston

Most recent South Central Houston hotel reviews