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Top trending hotels in South Central Houston

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

3.5 out of 5
6633 Travis St, Houston, TX
Fully refundableReserve now, pay when you stay
The price is AU$150 per night from 23 Dec to 24 Dec
AU$150
includes taxes & fees
23 Dec - 24 Dec
With a stay at Hilton Houston Plaza/Medical Center, you'll be centrally located in Houston, within a 5-minute drive of MD Anderson Cancer Center and Rice ...
Hilton Houston Plaza/Medical Center
InterContinental Houston, an IHG Hotel

InterContinental Houston, an IHG Hotel

4 out of 5
6750 Main St, Houston, TX
Fully refundable
The price is AU$262 per night from 28 Dec to 29 Dec
AU$262
includes taxes & fees
28 Dec - 29 Dec
With a stay at InterContinental Houston, an IHG Hotel, you'll be centrally located in Houston, within a 10-minute walk of Houston Methodist Hospital and Texas ...
InterContinental Houston, an IHG Hotel
Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 out of 5
5701 Main Street, Houston, TX
Fully refundableReserve now, pay when you stay
The price is AU$560 per night from 1 Jan to 2 Jan
AU$560
includes taxes & fees
1 Jan - 2 Jan 2025
With a stay at Hotel Zaza Houston Museum District, you'll be centrally located in Houston, within a 5-minute drive of MD Anderson Cancer Center and Toyota ...
Hotel Zaza Houston Museum District
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Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District

4 out of 5
6580 Fannin Street, Houston, TX
Fully refundableReserve now, pay when you stay
The price is AU$338 per night from 3 Jan to 4 Jan
AU$338
includes taxes & fees
3 Jan - 4 Jan 2025
With a stay at Houston Marriott Medical Center/Museum District in Houston (Texas Medical Center), you'll be steps from Houston Methodist Hospital and 3 minutes ...
Houston Marriott Medical Center/Museum District
The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District

4 out of 5
1709 DRYDEN ROAD, Houston, TX
Fully refundableReserve now, pay when you stay
The price is AU$303 per night from 29 Dec to 30 Dec
AU$303
includes taxes & fees
29 Dec - 30 Dec
With a stay at The Westin Houston Medical Center/Museum District in Houston (Texas Medical Center), you'll be within a 5-minute drive of Houston Zoo and Hermann ...
The Westin Houston Medical Center/Museum District
DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites

4 out of 5
6800 Main Street, Houston, TX
Fully refundableReserve now, pay when you stay
The price is AU$204 per night from 1 Jan to 2 Jan
AU$204
includes taxes & fees
1 Jan - 2 Jan 2025
Centrally located in Houston, DoubleTree by Hilton Houston Medical Center Hotel & Suites is within a 15-minute walk of MD Anderson Cancer Center and Hermann ...
DoubleTree by Hilton Houston Medical Center Hotel & Suites
SureStay Plus Hotel by Best Western Houston Medical Center

SureStay Plus Hotel by Best Western Houston Medical Center

2.5 out of 5
6700 Main Street, Houston, TX
With a stay at SureStay Plus Hotel by Best Western Houston Medical Center, you'll be centrally located in Houston, within a 5-minute drive of MD Anderson Cancer ...
SureStay Plus Hotel by Best Western Houston Medical Center
Americas Best Value Inn Medical Center Downtown

Americas Best Value Inn Medical Center Downtown

2 out of 5
2419 Riverside Dr, Houston, TX
Fully refundableReserve now, pay when you stay
The price is AU$124 per night from 23 Dec to 24 Dec
AU$124
includes taxes & fees
23 Dec - 24 Dec
A stay at Americas Best Value Inn Medical Center Downtown places you in the heart of Houston, within a 5-minute drive of Children's Museum of Houston and Houston ...
Americas Best Value Inn Medical Center Downtown
Extended Stay America Suites Houston Med Ctr Braeswood Bl

Extended Stay America Suites Houston Med Ctr Braeswood Bl

2.5 out of 5
1301 Braeswood Blvd, Houston, TX
Fully refundableReserve now, pay when you stay
The price is AU$152 per night from 5 Jan to 6 Jan
AU$152
includes taxes & fees
5 Jan - 6 Jan 2025
With a stay at Extended Stay America Suites Houston Med Ctr Braeswood Bl in Houston (Texas Medical Center), you'll be within a 5-minute drive of MD Anderson ...
Extended Stay America Suites Houston Med Ctr Braeswood Bl
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

South Central Houston Hotels

Haven’t you been dying to check out that swanky new coffee shop? What about the recently opened bar serving drinks in mason jars? And let’s not forget about the barber shops willing to give you a shaved-on-the-sides, long-on-top cut whenever you want. Don’t worry; we’ll help you find the best deals at hotels in South Central Houston.

This hip new ’hood will charm the-you-know-what off you. South Central Houston hotels are comfortable and affordable, and many offer amenities like room service for those late-night meals, as well as a pool to swim in. Some of these hotels will also have you near great shopping such as souvenir shops, clothing boutiques and everything in between. Don’t feel like leaving the hotel for dinner and drinks? Hang out in the lobby bar and meet some of your fellow travellers—you never what kinds of stories they have in their memory log.

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South Central Houston hotels essential information

Accommodation
1,208 hotels
Lowest Price
AU$124
Highest Price
AU$560
Popular hotels
Hilton Houston Plaza/Medical Center, InterContinental Houston, an IHG Hotel, Hotel Zaza Houston Museum District, Houston Marriott Medical Center/Museum District, The Westin Houston Medical Center/Museum District, DoubleTree by Hilton Houston Medical Center Hotel & Suites, SureStay Plus Hotel by Best Western Houston Medical Center, Americas Best Value Inn Medical Center Downtown, Extended Stay America Suites Houston Med Ctr Braeswood Bl

Most recent South Central Houston hotel reviews