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Featured Holiday Homes in St. Charles

Charming 1-bedroom house in delightful Winona with WiFi, AC and PRIVATE PATIO

Charming 1-bedroom house in delightful Winona with WiFi, AC and PRIVATE PATIO

Winona
With a stay at this vacation home, you'll be centrally located in Winona, within a 5-minute walk of Mississippi River and Watkins Heritage Museum.
Charming 1-bedroom house in delightful Winona with WiFi, AC and PRIVATE PATIO
Rural Winona Co. Guest House Getaway: Relax and Enjoy the Simple Things in Life

Rural Winona Co. Guest House Getaway: Relax and Enjoy the Simple Things in Life

Winona
With a stay at this vacation home in Winona, you'll be 12.1 mi (19.4 km) from Mississippi River and 10.2 mi (16.5 km) from Cedar Valley Golf Course.
Rural Winona Co. Guest House Getaway: Relax and Enjoy the Simple Things in Life
Century Cottage-PERFECT for Mayo & downtown visitors!

Century Cottage-PERFECT for Mayo & downtown visitors!

Rochester
With a stay at this vacation home, you'll be centrally located in Rochester, within a 5-minute drive of Mayo Clinic and Mayo Civic Center.
Century Cottage-PERFECT for Mayo & downtown visitors!
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Delightful family home near parks, nature center, 1.5 m to Mayo Clinic downtown

Delightful family home near parks, nature center, 1.5 m to Mayo Clinic downtown

Rochester
With a stay at this vacation home in Rochester, you'll be within a 5-minute drive of Mayo Clinic and Mayo Civic Center.
Delightful family home near parks, nature center, 1.5 m to Mayo Clinic downtown
1 mi. from Mayo Clinic; Cozy, Clean

1 mi. from Mayo Clinic; Cozy, Clean

Rochester
With a stay at this vacation home, you'll be centrally located in Rochester, within a 5-minute drive of Mayo Clinic and Mayo Clinic Hospital - Saint Marys ...
1 mi. from Mayo Clinic; Cozy, Clean
NEW Listing - Entertainment for the whole family. Sleeps up to 12.

NEW Listing - Entertainment for the whole family. Sleeps up to 12.

Rochester
With a stay at this vacation home in Rochester, you'll be a 5-minute drive from Mayo Civic Center and 6 minutes from Mayo Clinic.
NEW Listing - Entertainment for the whole family. Sleeps up to 12.
Park-Side, Easy Access To Downtown, Mayo Clinic & Bike Trail, Family-Friendly

Park-Side, Easy Access To Downtown, Mayo Clinic & Bike Trail, Family-Friendly

Rochester
With a stay at this vacation home in Rochester (Slatterly Park), you'll be within a 5-minute drive of Mayo Clinic and Mayo Civic Center.
Park-Side, Easy Access To Downtown, Mayo Clinic & Bike Trail, Family-Friendly
Bluffside cottage with gorgeous river views

Bluffside cottage with gorgeous river views

Fountain City
When you stay at this vacation home in Fountain City, you'll be on a river, just steps from Mississippi River and 13 minutes by foot from Rock in the House.
Bluffside cottage with gorgeous river views
Fresh space near Mayo Clinic and downtown

Fresh space near Mayo Clinic and downtown

Rochester
With a stay at this vacation home in Rochester (Slatterly Park), you'll be within a 5-minute drive of Mayo Clinic and Mayo Civic Center.
Fresh space near Mayo Clinic and downtown
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

St. Charles Holiday Houses

Do you love last minute road trips and late-night food runs and sunrises on the beach? Do words like “schedule” and “calendar” make you shout, “Don’t box me in!”? You might be a little bit of a rebel. But you’re a rebel with a cause: having a smashing holiday. Itinerary? What’s that? Our St. Charles vacation homes are the perfect way for you to wing it.

Holiday houses in St. Charles let you live life on your own terms. You’ll have so much space, you’ll wish you had more friends and family—but you can always invite over the neighbours. You can often have luxury amenities, but with all the attractions of St. Charles in your backyard, budget holiday homes will do just fine, too. That will just leave you more dough to spend on the important things: cocktails, brunch, and local St. Charles adventures, obvs.

If your adventure buddy happens to have fur and four legs, you just might find a pet-friendly holiday house in St. Charles with your name on it.

No need to spend big bickies for a holiday beach house the size of Buckingham Palace—unless you’re really in trouble with bae. We’ve got a great selection of St. Charles vacation homes with everything you need for a seriously amazing getaway. Throw out that daily planner and hit “reject” on all those meeting invites. You’re off to a place where there are no rules.

St. Charles Holiday Homes essential information

Accommodation
197 Holiday Homes
Lowest Price
AU$140
Highest Price
AU$298
Popular accommodation
Charming 1-bedroom house in delightful Winona with WiFi, AC and PRIVATE PATIO, Rural Winona Co. Guest House Getaway: Relax and Enjoy the Simple Things in Life, Century Cottage-PERFECT for Mayo & downtown visitors!, Delightful family home near parks, nature center, 1.5 m to Mayo Clinic downtown , 1 mi. from Mayo Clinic; Cozy, Clean, NEW Listing - Entertainment for the whole family. Sleeps up to 12. , Park-Side, Easy Access To Downtown, Mayo Clinic & Bike Trail, Family-Friendly, Bluffside cottage with gorgeous river views, Fresh space near Mayo Clinic and downtown

Top trending hotels in St. Charles

AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic

3 out of 5
1625 Broadway Ave S, Rochester, MN
Fully refundableReserve now, pay when you stay
The price is AU$140 per night from 13 Apr to 14 Apr
AU$140
includes taxes & fees
13 Apr - 14 Apr
When you stay at AmericInn by Wyndham Rochester Near Mayo Clinic in Rochester, you'll be in a shopping district, within a 5-minute drive of Olmsted County Fairgrounds ...
AmericInn by Wyndham Rochester Near Mayo Clinic
Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
20 2nd Ave Sw, Rochester, MN
Fully refundableReserve now, pay when you stay
The price is AU$298 per night from 4 Apr to 5 Apr
AU$298
includes taxes & fees
4 Apr - 5 Apr
A stay at Kahler Grand Hotel places you in the heart of Rochester, within a 5-minute walk of Mayo Clinic and University of Minnesota-Rochester.
Kahler Grand Hotel
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

3.5 out of 5
9 3rd Ave Nw, Rochester, MN
Fully refundableReserve now, pay when you stay
The price is AU$269 per night from 11 Apr to 12 Apr
AU$269
includes taxes & fees
11 Apr - 12 Apr
Kahler Inn and Suites - Mayo Clinic Area is centrally located in Rochester, a 3-minute walk from Mayo Clinic and 7 minutes by foot from University of ...
Kahler Inn and Suites - Mayo Clinic Area
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Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

3 out of 5
110 Civic Center Drive NW, Rochester, MN
Fully refundableReserve now, pay when you stay
The price is AU$190 per night from 18 Apr to 19 Apr
AU$190
includes taxes & fees
18 Apr - 19 Apr
With a stay at Hyatt House Rochester/Mayo Clinic Area, you'll be centrally located in Rochester, within a 10-minute walk of University of Minnesota-Rochester ...
Hyatt House Rochester/Mayo Clinic Area
Don't see what you're looking for?
See all available properties in St. Charles
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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^Subject to availability and chosen travel dates.