The Perapolis Hotel is located in a very interesting area with great restaurants and shops near the Hagia Sophia and Topkapi Palace. If you are touring, this place is in a great location.
The hotel gets some western guests, and the front desk speaks English pretty well. They're very obliging - they arranged two tours for me and sent out my laundry to be done. Judging from my fellow guests at breakfast (included), most people who stay here are clerics or Turkish people.
The room I had was on the ground floor behind the reception, so it was a bit noisy during the early evening. Comfortable bed and a nice bathroom.
A few negatives, however. The foot of the bed was almost up against the opposite wall, and the television was hung on the wall, so it was difficult accessing the far side of the bed without whacking yourself on the TV. Since I was visiting on my own, this wasn't an issue, but two people might not like the room. Also, there was a good sized closet and a safe, but no place to put a suitcase. I ended up with mine on the floor by the door.
However, because of the great location and the service, I would certainly stay here again.