Book Holiday Homes in Seneca

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Featured Holiday Homes in Seneca

Lake Keowee waterfront Escape!

Lake Keowee waterfront Escape!

West Union
Located in West Union, this vacation home is on the waterfront, within a 15-minute drive of Lake Keowee and Art Circle Gallery.
Lake Keowee waterfront Escape!
Lake Hartwell - House w/dock, screened in porch and firepit

Lake Hartwell - House w/dock, screened in porch and firepit

Martin
When you stay at this vacation home in Martin, you'll be on the waterfront and steps from Lake Hartwell.
Lake Hartwell - House w/dock, screened in porch and firepit
Home Game Weekender in Clemson - Spacious 5 Bed/4 Bath

Home Game Weekender in Clemson - Spacious 5 Bed/4 Bath

2 out of 5
Clemson
With a stay at this vacation home in Clemson, you'll be within a 5-minute drive of Clemson University and Clemson Area African American Museum.
Home Game Weekender in Clemson - Spacious 5 Bed/4 Bath
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2-209C - Coopers Cozy Cabin ^ Lake Hartwell ^ WIFI ^ Pets Welcome

2-209C - Coopers Cozy Cabin ^ Lake Hartwell ^ WIFI ^ Pets Welcome

Martin
When you stay at this vacation home in Martin, you'll be on the waterfront and steps from Lake Hartwell.
2-209C - Coopers Cozy Cabin ^ Lake Hartwell ^ WIFI ^ Pets Welcome
Gorgeous remodeled waterfront home for 12: pets welcome, covered deck, boat dock

Gorgeous remodeled waterfront home for 12: pets welcome, covered deck, boat dock

Lavonia
With a stay at this vacation home in Lavonia, you'll be on the waterfront, just steps from Lake Hartwell and a 4-minute drive from Party Island.
Gorgeous remodeled waterfront home for 12: pets welcome, covered deck, boat dock
Lake Keowee Escape w/ Dock, Deck & Lake Access!

Lake Keowee Escape w/ Dock, Deck & Lake Access!

Six Mile
Located in Six Mile, this vacation home is on the waterfront, a 1-minute drive from Lake Keowee and 7 minutes from Keowee Key Golf Course.
Lake Keowee Escape w/ Dock, Deck & Lake Access!
The Brick House At Currahee

The Brick House At Currahee

Toccoa
The price is AU$336 per night from 26 Nov to 27 Nov
AU$336
includes taxes & fees
26 Nov - 27 Nov
With a stay at this vacation home in Toccoa, you'll be steps from Chattahoochee National Forest and a 3-minute drive from Currahee Military Museum.
The Brick House At Currahee
Keowee Key Townhome #3 With a View of Golf Course plus Amenities

Keowee Key Townhome #3 With a View of Golf Course plus Amenities

Salem
With a stay at this vacation home in Salem, you'll be next to a golf course, just a 1-minute walk from Keowee Key Golf Course and 11 minutes by foot from South ...
Keowee Key Townhome #3 With a View of Golf Course plus Amenities
EXCEPTIONAL, SUPER CLEAN! IN THE FOOTHILLS OF THE BLUE RIDGE MTN.! NO ANIMALS!

EXCEPTIONAL, SUPER CLEAN! IN THE FOOTHILLS OF THE BLUE RIDGE MTN.! NO ANIMALS!

Pickens
Located in Pickens, this vacation home is in the mountains, within a 5-minute drive of AnMed Health Cannon and Pickens City Hall.
EXCEPTIONAL, SUPER CLEAN! IN THE FOOTHILLS OF THE BLUE RIDGE MTN.! NO ANIMALS!
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Seneca Holiday Houses

Do you love last minute road trips and late-night food runs and sunrises on the beach? Do words like “schedule” and “calendar” make you shout, “Don’t box me in!”? You might be a little bit of a rebel. But you’re a rebel with a cause: having a smashing holiday. Itinerary? What’s that? Our Seneca vacation homes are the perfect way for you to wing it.

Holiday houses in Seneca let you live life on your own terms. You’ll have so much space, you’ll wish you had more friends and family—but you can always invite over the neighbours. You can often have luxury amenities, but with all the attractions of Seneca in your backyard, budget holiday homes will do just fine, too. That will just leave you more dough to spend on the important things: cocktails, brunch, and local Seneca adventures, obvs.

If your adventure buddy happens to have fur and four legs, you just might find a pet-friendly holiday house in Seneca with your name on it.

No need to spend big bickies for a holiday beach house the size of Buckingham Palace—unless you’re really in trouble with bae. We’ve got a great selection of Seneca vacation homes with everything you need for a seriously amazing getaway. Throw out that daily planner and hit “reject” on all those meeting invites. You’re off to a place where there are no rules.

Seneca Holiday Homes essential information

Accommodation
570 Holiday Homes
Lowest Price
AU$136
Highest Price
AU$336
Popular accommodation
Lake Keowee waterfront Escape!, Lake Hartwell - House w/dock, screened in porch and firepit, Home Game Weekender in Clemson - Spacious 5 Bed/4 Bath, 2-209C - Coopers Cozy Cabin ^ Lake Hartwell ^ WIFI ^ Pets Welcome, Gorgeous remodeled waterfront home for 12: pets welcome, covered deck, boat dock, Lake Keowee Escape w/ Dock, Deck & Lake Access!, The Brick House At Currahee, Keowee Key Townhome #3 With a View of Golf Course plus Amenities, EXCEPTIONAL, SUPER CLEAN! IN THE FOOTHILLS OF THE BLUE RIDGE MTN.! NO ANIMALS!

Top trending hotels in Seneca

Lakeside Lodge Clemson

Lakeside Lodge Clemson

2.5 out of 5
13500 Clemson Blvd, Seneca, SC
Fully refundableReserve now, pay when you stay
The price is AU$207 per night from 26 Nov to 27 Nov
AU$207
includes taxes & fees
26 Nov - 27 Nov
With a stay at Lakeside Lodge Clemson in Seneca, you'll be within a 5-minute drive of Clemson University and Lake Hartwell.
Lakeside Lodge Clemson
Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson

2.5 out of 5
13050 Clemson Blvd, Seneca, SC
The price is AU$185 per night from 26 Dec to 27 Dec
AU$185
includes taxes & fees
26 Dec - 27 Dec
When you stay at Tru by Hilton Seneca Clemson in Seneca, you'll be in a shopping district, within a 5-minute drive of Clemson University and Littlejohn ...
Tru by Hilton Seneca Clemson
Quality Inn Seneca US-123

Quality Inn Seneca US-123

2.5 out of 5
226 Hi Tech Rd, Seneca, SC
Fully refundableReserve now, pay when you stay
The price is AU$136 per night from 16 Dec to 17 Dec
AU$136
includes taxes & fees
16 Dec - 17 Dec
With a stay at Quality Inn Seneca US-123, you'll be centrally located in Seneca, within a 15-minute drive of Clemson University and The Gauntlet.
Quality Inn Seneca US-123
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Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

2.5 out of 5
1011 East North 1st Street, Seneca, SC
Fully refundableReserve now, pay when you stay
The price is AU$217 per night from 8 Dec to 9 Dec
AU$217
includes taxes & fees
8 Dec - 9 Dec
With a stay at Hampton Inn & Suites Seneca-Clemson Area in Seneca, you'll be in the business district, within a 10-minute drive of Clemson University and Wyndham ...
Hampton Inn & Suites Seneca-Clemson Area
Don't see what you're looking for?
See all available properties in Seneca
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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^Subject to availability and chosen travel dates.