Book Southern Illinois hotels

More Flash, Less Cash - Take advantage of our Price Pledge** (even on luxey stays)

We keep it easy with the option to pay now or later on select accommodation

Book up 'til the last second - millions of rooms to crash tonight^

Check hotel availability in Southern Illinois

Cheap Southern Illinois hotels

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

3 out of 5
145 North 44th Street , Mount Vernon, IL
Fully refundableReserve now, pay when you stay
The price is AU$183 per night from 4 May to 5 May
AU$183
includes taxes & fees
4 May - 5 May
A stay at Drury Plaza Hotel Mt. Vernon places you in the heart of Mount Vernon, within a 5-minute drive of King City Square Shopping Center and Crossroads Community ...
Drury Plaza Hotel Mt. Vernon
Super 8 by Wyndham O'Fallon

Super 8 by Wyndham O'Fallon

2 out of 5
1100 Eastgate Dr, O'Fallon, IL
Fully refundableReserve now, pay when you stay
The price is AU$93 per night from 5 May to 6 May
AU$93
includes taxes & fees
5 May - 6 May
Located in O'Fallon, Super 8 by Wyndham O'Fallon is within a 10-minute drive of Shiloh Dog Park and Scott Air Force Base.
Super 8 by Wyndham O'Fallon
Quality Inn & Suites near St. Louis and I-255

Quality Inn & Suites near St. Louis and I-255

2.5 out of 5
1607 Pontiac Dr, East St. Louis, IL
Fully refundableReserve now, pay when you stay
The price is AU$118 per night from 18 May to 19 May
AU$118
includes taxes & fees
18 May - 19 May
With a stay at Quality Inn & Suites near St. Louis and I-255, you'll be centrally located in East St. Louis, within a 15-minute drive of Busch Stadium and Enterprise ...
Quality Inn & Suites near St. Louis and I-255
Save an average of 15% on thousands of hotels when you're signed in
Drury Inn & Suites Marion

Drury Inn & Suites Marion

3 out of 5
2706 W DeYoung St, Marion, IL
The price is AU$210 per night from 4 May to 5 May
AU$210
includes taxes & fees
4 May - 5 May
A stay at Drury Inn & Suites Marion places you in the heart of Marion, within a 5-minute drive of Kokopelli Golf Club and Marion Stadium.
Drury Inn & Suites Marion
Drury Inn & Suites St. Louis O'Fallon, IL

Drury Inn & Suites St. Louis O'Fallon, IL

3 out of 5
1118 Central Park Drive, O'Fallon, IL
Fully refundableReserve now, pay when you stay
The price is AU$192 per night from 4 May to 5 May
AU$192
includes taxes & fees
4 May - 5 May
A stay at Drury Inn & Suites St. Louis O'Fallon, IL places you in the heart of O'Fallon, within a 5-minute drive of HSHS St. Elizabeth's Hospital and Clayton ...
Drury Inn & Suites St. Louis O'Fallon, IL
Comfort Suites Mount Vernon

Comfort Suites Mount Vernon

2.5 out of 5
404 South 44th Street, Mount Vernon, IL
Fully refundableReserve now, pay when you stay
The price is AU$191 per night from 13 May to 14 May
AU$191
includes taxes & fees
13 May - 14 May
A stay at Comfort Suites Mount Vernon places you in the heart of Mount Vernon, within a 5-minute drive of King City Square Shopping Center and Crossroads Community ...
Comfort Suites Mount Vernon
Red Lion Inn & Suites Pontoon Beach

Red Lion Inn & Suites Pontoon Beach

2.5 out of 5
1240 E Chain Of Rocks Rd, Granite City, IL
Fully refundableReserve now, pay when you stay
The price is AU$121 per night from 13 May to 14 May
AU$121
includes taxes & fees
13 May - 14 May
With a stay at Red Lion Inn & Suites Pontoon Beach in Granite City, you'll be within a 10-minute drive of Horseshoe Lake State Park and Lewis and Clark Interpretive ...
Red Lion Inn & Suites Pontoon Beach
Baymont by Wyndham Marion

Baymont by Wyndham Marion

2.5 out of 5
2608 W Main St, Marion, IL
The price is AU$161 per night from 12 May to 13 May
AU$161
includes taxes & fees
12 May - 13 May
With a stay at Baymont by Wyndham Marion in Marion, you'll be within a 5-minute drive of The Bark Park and Williamson County Historical Museum.
Baymont by Wyndham Marion
Drury Inn & Suites St. Louis Fairview Heights

Drury Inn & Suites St. Louis Fairview Heights

3 out of 5
12 Ludwig Dr, Fairview Heights, IL
Fully refundableReserve now, pay when you stay
The price is AU$198 per night from 4 May to 5 May
AU$198
includes taxes & fees
4 May - 5 May
Located in Fairview Heights, Drury Inn & Suites St. Louis Fairview Heights is within a 15-minute drive of Mississippi River and America's Center Convention ...
Drury Inn & Suites St. Louis Fairview Heights
Don't see what you're looking for?
See all available properties in Southern Illinois
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

**Terms and Conditions apply.
^Subject to availability and chosen travel dates.

Southern Illinois hotels essential information

Accommodation
983 hotels
Lowest Price
AU$93
Highest Price
AU$210
Popular hotels
Drury Plaza Hotel Mt. Vernon, Super 8 by Wyndham O'Fallon, Quality Inn & Suites near St. Louis and I-255, Drury Inn & Suites Marion, Drury Inn & Suites St. Louis O'Fallon, IL, Comfort Suites Mount Vernon, Red Lion Inn & Suites Pontoon Beach, Baymont by Wyndham Marion, Drury Inn & Suites St. Louis Fairview Heights

Most recent Southern Illinois hotel reviews

**Terms and Conditions apply.
^Subject to availability and chosen travel dates.