Find Serra Mesa hotels

More Flash, Less Cash - Take advantage of our Price Pledge** (even on luxey stays)

We keep it easy with the option to pay now or later on select accommodation

Book up 'til the last second - millions of rooms to crash tonight^

Check hotel availability in Serra Mesa

Top trending hotels in Serra Mesa

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

2.5 out of 5
2485 Hotel Circle Place, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is AU$214 per night from 23 Mar to 24 Mar
AU$214
includes taxes & fees
23 Mar - 24 Mar
Located in San Diego (Mission Valley), Best Western Inn & Suites San Diego – Zoo/SeaWorld Area is within a 5-minute drive of Hotel Circle and University of San ...
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
San Diego Mission Bay Resort

San Diego Mission Bay Resort

4 out of 5
1775 E Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is AU$444 per night from 16 Mar to 17 Mar
AU$444
includes taxes & fees
16 Mar - 17 Mar
Located in San Diego, San Diego Mission Bay Resort is on the boardwalk/promenade, a 4-minute drive from University of San Diego and 9 minutes from San Diego ...
San Diego Mission Bay Resort
Comfort Inn Sea World Area

Comfort Inn Sea World Area

3.5 out of 5
3880 Greenwood St, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is AU$193 per night from 26 Mar to 27 Mar
AU$193
includes taxes & fees
26 Mar - 27 Mar
Located in San Diego (Point Loma), Comfort Inn Sea World Area is within a 10-minute drive of Marine Corps Recruit Depot and San Diego Convention Center.
Comfort Inn Sea World Area
Save an average of 15% on thousands of hotels when you're signed in
The Little Italy Hotel Downtown San Diego

The Little Italy Hotel Downtown San Diego

4 out of 5
1646 Front St, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is AU$241 per night from 16 Mar to 17 Mar
AU$241
includes taxes & fees
16 Mar - 17 Mar
In the heart of San Diego, The Little Italy Hotel Downtown San Diego is within a 5-minute drive of Waterfront Park and San Diego Convention Center.
The Little Italy Hotel Downtown San Diego
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is AU$271 per night from 13 Apr to 14 Apr
AU$271
includes taxes & fees
13 Apr - 14 Apr
In the heart of San Diego, Wyndham San Diego Bayside is within a 5-minute drive of USS Midway Museum and San Diego Convention Center.
Wyndham San Diego Bayside
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is AU$319 per night from 23 Mar to 24 Mar
AU$319
includes taxes & fees
23 Mar - 24 Mar
With a stay at The Dana on Mission Bay, you'll be centrally located in San Diego, within a 5-minute drive of Mission Bay and Mission Beach Boardwalk.
The Dana on Mission Bay
Humphreys Half Moon Inn

Humphreys Half Moon Inn

3.5 out of 5
2303 Shelter Island Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is AU$303 per night from 16 Mar to 17 Mar
AU$303
includes taxes & fees
16 Mar - 17 Mar
With a stay at Humphreys Half Moon Inn in San Diego (Point Loma), you'll be steps from Shelter Island and 5 minutes by foot from Naval Base Coronado.
Humphreys Half Moon Inn
San Diego Marriott La Jolla

San Diego Marriott La Jolla

4 out of 5
4240 La Jolla Village Dr, La Jolla, CA
Fully refundableReserve now, pay when you stay
The price is AU$257 per night from 14 Mar to 15 Mar
AU$257
includes taxes & fees
14 Mar - 15 Mar
Located in La Jolla (University City), San Diego Marriott La Jolla is within a 10-minute walk of University of California, San Diego and Westfield UTC.
San Diego Marriott La Jolla
Inn By The Sea La Jolla

Inn By The Sea La Jolla

3.5 out of 5
7830 Fay Ave, La Jolla, CA
Fully refundableReserve now, pay when you stay
The price is AU$404 per night from 16 Mar to 17 Mar
AU$404
includes taxes & fees
16 Mar - 17 Mar
With a stay at Inn By The Sea La Jolla in La Jolla (Village of La Jolla), you'll be a 3-minute drive from La Jolla Cove and 8 minutes from Mission Bay.
Inn By The Sea La Jolla
Don't see what you're looking for?
See all available properties in Serra Mesa
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Serra Mesa Hotels

Haven’t you been dying to check out that swanky new coffee shop? What about the recently opened bar serving drinks in mason jars? And let’s not forget about the barber shops willing to give you a shaved-on-the-sides, long-on-top cut whenever you want. Don’t worry; we’ll help you find the best deals at hotels in Serra Mesa.

This hip new ’hood will charm the-you-know-what off you. Serra Mesa hotels are comfortable and affordable, and many offer amenities like room service for those late-night meals, as well as a pool to swim in. Some of these hotels will also have you near great shopping such as souvenir shops, clothing boutiques and everything in between. Don’t feel like leaving the hotel for dinner and drinks? Hang out in the lobby bar and meet some of your fellow travellers—you never what kinds of stories they have in their memory log.

There’s no point in going somewhere if you’re not going to stay where all the action is. lastminute.com.au gets you the best offers on where to stay in Serra Mesa so you don’t have to waste endless hours searching online. The trip of a lifetime is at your fingertips. Click and go!

Serra Mesa hotels essential information

Accommodation
8,675 hotels
Lowest Price
AU$193
Highest Price
AU$444
Popular hotels
The Dana on Mission Bay, San Diego Marriott La Jolla, Best Western Inn & Suites San Diego – Zoo/SeaWorld Area , San Diego Mission Bay Resort, Wyndham San Diego Bayside, Comfort Inn Sea World Area, Inn By The Sea La Jolla, Humphreys Half Moon Inn, The Little Italy Hotel Downtown San Diego

Most recent Serra Mesa hotel reviews