Find Medical Center District hotels

More Flash, Less Cash - Take advantage of our Price Pledge** (even on luxey stays)

We keep it easy with the option to pay now or later on select accommodation

Book up 'til the last second - millions of rooms to crash tonight^

Check hotel availability in Medical Center District

Top trending hotels in Medical Center District

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

2.5 out of 5
4431 Horizon Hill Blvd, San Antonio, TX
Fully refundableReserve now, pay when you stay
The price is AU$160 per night from 27 Apr to 28 Apr
AU$160
includes taxes & fees
27 Apr - 28 Apr
With a stay at La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW in San Antonio (Medical Center District), you'll be a 4-minute drive from University ...
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410, San Antonio, TX
Fully refundableReserve now, pay when you stay
The price is AU$183 per night from 11 May to 12 May
AU$183
includes taxes & fees
11 May - 12 May
With a stay at San Antonio Marriott Northwest Medical Center in San Antonio (Medical Center District), you'll be within a 10-minute drive of North Star Mall ...
San Antonio Marriott Northwest Medical Center
Drury Inn & Suites San Antonio Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center

3 out of 5
9806 Interstate Hwy 10 W, San Antonio, TX
Fully refundableReserve now, pay when you stay
The price is AU$184 per night from 27 Apr to 28 Apr
AU$184
includes taxes & fees
27 Apr - 28 Apr
With a stay at Drury Inn & Suites San Antonio Northwest Medical Center in San Antonio (Medical Center District), you'll be a 4-minute drive from USAA Corporate ...
Drury Inn & Suites San Antonio Northwest Medical Center
Save an average of 15% on thousands of hotels when you're signed in
Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk

3 out of 5
105 S Saint Marys Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
The price is AU$221 per night from 14 May to 15 May
AU$221
includes taxes & fees
14 May - 15 May
A stay at Drury Plaza Hotel San Antonio Riverwalk places you in the heart of San Antonio, steps from River Walk and San Antonio River.
Drury Plaza Hotel San Antonio Riverwalk
Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street, Dwyer/Main Plaza, San Antonio, TX
Fully refundableReserve now, pay when you stay
The price is AU$161 per night from 19 May to 20 May
AU$161
includes taxes & fees
19 May - 20 May
With a stay at Riverwalk Plaza, you'll be centrally located in San Antonio, steps from San Antonio River and 3 minutes by foot from River Walk.
Riverwalk Plaza
Menger Hotel

Menger Hotel

3.5 out of 5
204 Alamo Plaza, San Antonio, TX
Fully refundableReserve now, pay when you stay
The price is AU$225 per night from 6 May to 7 May
AU$225
includes taxes & fees
6 May - 7 May
With a stay at Menger Hotel, you'll be centrally located in San Antonio, steps from Alamo and Ripley's Believe It or Not!.
Menger Hotel
Sonesta ES Suites San Antonio Downtown Alamo Plaza

Sonesta ES Suites San Antonio Downtown Alamo Plaza

3 out of 5
425 Bonham, San Antonio, TX
Fully refundableReserve now, pay when you stay
The price is AU$179 per night from 18 May to 19 May
AU$179
includes taxes & fees
18 May - 19 May
Sonesta ES Suites San Antonio Downtown Alamo Plaza is centrally located in San Antonio, a 4-minute walk from Shops at Rivercenter and 6 minutes by foot from ...
Sonesta ES Suites San Antonio Downtown Alamo Plaza
Crockett Hotel

Crockett Hotel

3 out of 5
320 Bonham, San Antonio, TX
Fully refundableReserve now, pay when you stay
The price is AU$193 per night from 14 May to 15 May
AU$193
includes taxes & fees
14 May - 15 May
Crockett Hotel is in the heart of San Antonio, within a 5-minute walk of Alamo and Guinness World Records Museum.
Crockett Hotel
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

3 out of 5
303 Blum Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
The price is AU$177 per night from 23 Apr to 24 Apr
AU$177
includes taxes & fees
23 Apr - 24 Apr
With a stay at La Quinta Inn & Suites by Wyndham San Antonio Riverwalk, you'll be centrally located in San Antonio, steps from Shops at Rivercenter and within ...
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
Don't see what you're looking for?
See all available properties in Medical Center District
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Medical Center District Hotels

Haven’t you been dying to check out that swanky new coffee shop? What about the recently opened bar serving drinks in mason jars? And let’s not forget about the barber shops willing to give you a shaved-on-the-sides, long-on-top cut whenever you want. Don’t worry; we’ll help you find the best deals at hotels in Medical Center District.

This hip new ’hood will charm the-you-know-what off you. Medical Center District hotels are comfortable and affordable, and many offer amenities like room service for those late-night meals, as well as a pool to swim in. Some of these hotels will also have you near great shopping such as souvenir shops, clothing boutiques and everything in between. Don’t feel like leaving the hotel for dinner and drinks? Hang out in the lobby bar and meet some of your fellow travellers—you never what kinds of stories they have in their memory log.

There’s no point in going somewhere if you’re not going to stay where all the action is. lastminute.com.au gets you the best offers on where to stay in Medical Center District so you don’t have to waste endless hours searching online. The trip of a lifetime is at your fingertips. Click and go!

Medical Center District hotels essential information

Accommodation
4,289 hotels
Lowest Price
AU$160
Highest Price
AU$225
Popular hotels
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW, San Antonio Marriott Northwest Medical Center, Drury Inn & Suites San Antonio Northwest Medical Center, Riverwalk Plaza, La Quinta Inn & Suites by Wyndham San Antonio Riverwalk, Crockett Hotel, Drury Plaza Hotel San Antonio Riverwalk, Menger Hotel, Sonesta ES Suites San Antonio Downtown Alamo Plaza

Most recent Medical Center District hotel reviews